32 research outputs found

    Mitochondrial physiology

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    As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

    Mitochondrial physiology

    Get PDF
    As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

    Journalistic views on post-violent peacebuilding in Bosnia and Herzegovina

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    In this chapter we focus on the media portrayal content of a specific ­traumatic event and journalists’ discourse about it in Bosnia and Herzegovina (BIH). Despite the growing role and authority of journalists in shaping our understanding of collective pasts, the possible role of journalists as active agents in contributing to heightening tensions has been marginalized. Analyzing media texts can demonstrate how a “specific, limited truth” about the start of war in BIH is being selected, instrumentalized, and legitimized in the public awareness. Focus on journalists’ perceptions of war and positive post-violence offers an understanding of different views about the start of the war, and guilt. This is why the basic research questions here deal with how journalists in BIH represent the violent past. Specifically, how do they cover a specific traumatic event and what are their perceptions about possibilities of realizing positive post-violence? Research on post-conflict processes looks at the ways in which people attempt to recreate their social fabric in ways appropriated to the changes in their social environment. Thus, the larger question that we are interested in here is whether journalists, like storytellers, frame their stories according to their ethnical belonging and the cultural environment? Furthermore, what media conditions might make possible positive post-violence after violent conflict
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